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New study confirms link between over-reliance on SABA inhalers and increase in asthma exacerbations


A new study published in The Advances in Therapy journal, using real world-data confirms a link between over-reliance on SABA inhalers and an increase in asthma exacerbations and asthma-related healthcare utilisation

The SABINA (SABA use IN Asthma) study examined prescription patterns and the impact of SABA inhaler use on asthma-related health outcomes in the UK.    Data from more than half a million patients over 12 years old found that over 200,000 people (38%) were classified as having high SABA inhaler use (prescribed ≥3 inhalers/year) which was associated with approximately twice the number of asthma attacks compared with low users (prescribed 0-2 inhalers/year), regardless of asthma severity.  High SABA inhaler use was associated with an increased risk of exacerbations compared to low SABA inhaler users.

This retrospective, longitudinal, open-cohort study used data from the Clinical Practice Research Datalink (CPRD) and Hospital Episode Statistics (HES) database between 2007-2017. Patient prescription data and treatment steps were reviewed when considering their use of SABA, both separately, and with outcomes of exacerbations or asthma-related healthcare utilisation.

5.4 million people (4.3 million adults) live with asthma in the UK.   Every 10 seconds someone in the UK has a potentially life-threatening asthma attack, with on average, three people dying from asthma every day.    

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More resources to support you to help your patients overcome SABA overreliance can be found on our Asthma Right Care web pages.